The Supreme Court will hear oral arguments Wednesday over Tennessee’s ban on gender-affirming care for minors, a landmark case that will have implications nationwide as Republicans have increasingly targeted transgender rights and enacted bans on healthcare for minors across the country.

The highest court in the United States is set to decide whether a statewide ban in Tennessee on gender-affirming medical care for minors is unconstitutional. The landmark case could have major consequences for transgender people across the country.

The ruling could set a precedent for several challenges to state laws regarding sports participation, bathroom use and health care for adults.

The Supreme Court hears oral arguments on the ability of states to restrict treatments for minors whose gender identity doesn't align with their sex assigned at birth.

There was a clarifying moment late in Wednesday’s two-and-a-half-hour-long oral argument in United States v. Skrmetti, a history-making challenge to Tennessee’s ban on gender-affirming care for minors.

Court documents referred to ACLU lawyer Chase Strangio, a biological female who identifies as a man and uses male pronouns, as "Mr."

The Supreme Court appeared split along ideological lines as it debated whether bans on puberty blockers for transgender minors are discriminatory.