The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

Quarterback Brock Purdy did not waste any time in getting the ball into the hands of 49ers tight end George Kittle on Sunday.

After Sunday night's humbling loss in snowy Buffalo, it's time for Kyle Shanahan and John Lynch to start shutting ...

The San Francisco 49ers entered Sunday's game at Lambeau Field against the Green Bay Packers at a clear disadvantage. They ...

These are the cold, hard facts. The 49ers received another snowball upside their heads — figuratively and, perhaps, literally ...

The 49ers' run game was going well until it wasn't in their 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium.

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their ...

The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 ...

The San Francisco 49ers suffered another crushing defeat Sunday night, falling 35-10 to the Buffalo Bills. The loss marked ...