Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

It’s been a trying season for the 49ers. After going through multiple unthinkable experiences and the unavoidable injury bug, ...

The 49ers have lost three games in a row, but their season isn't dead yet. Sure, they're in last place in the NFC West, but ...

The 49ers brass — Kyle Shanahan, John Lynch, and CEO Jed York chief among them — have not wavered on their commitment to ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

San Francisco 49ers' Trent Williams' wife Sondra has announced the death of their baby son at 35 weeks after losing his twin ...

The San Francisco 49ers' hangover from their Super Bowl LIVIII defeat to the Kansas City Chiefs has stretched into the 2024 ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian ...

Currently the San Francisco 49ers are 18th in the NFL in terms of odds to win the Super Bowl, listed at +15000. The 49ers squared off against the Buffalo Bills in their most recent outing ...