The San Francisco 49ers face a pivotal offseason as their once-promising season spirals further from playoff contention.

Rookie Isaac Guerendo steps up as 49ers seek to fill void left by McCaffrey and injured backup Jordan Mason. Coach Shanahan ...

The San Francisco 49ers' playoff chances took a significant hit Sunday following a 35-10 loss to the Buffalo Bills at ...

The first games of the holiday season are in the books as the road to the NFL playoffs continues. Week 13 saw a stereotypical ...

The San Francisco 49ers injury list continues to grow in the second half of the season. Following their Week 13 loss to the ...

Christian McCaffrey may have suffered an isolated PCL tear against the Buffalo Bills, a rare injury that could end his season ...

After missing the first eight games with an Achilles injury to begin the season, running back Christian McCaffrey will be ...

Former Mexican boxer Israel Vazquez, who won three junior featherweight world titles, died after battling cancer, World ...

Let's take a look back at how the previous Madden cover stars have fared to see if the 49ers star RB has anything to fear ...

Ja'Quan McMillian jumped a route in the flat and snatched the football for an interception in front of Elijah Moore, sealing ...

Running back Christian McCaffrey will go on injured reserve with a posterior cruciate ligament strain that may not need ...

On a night when Josh Allen threw a touchdown pass and scored one on the same play, the strangest sight at snowy Highmark ...