One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

Deebo Samuel speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium.Deebo ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

The Buffalo Bills clinched their fifth straight AFC East division championship by defeating the San Francisco 49ers 34-10 ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

ORCHARD PARK, NEW YORK – DECEMBER 01: Mack Hollins #13 of the Buffalo Bills celebrates after scoring a touchdown in the ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

San Francisco 49ers wide receiver Deebo Samuel returns the half-opening kick 60 yards into Buffalo Bills territory.