San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San Francisco 49ers.

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of ...

RB Christian McCaffrey looked to finally be taking off after his return from an Achilles injury but suffered a PCL injury ...

Both of these teams are nowhere near where they'd like to be this season, but with one finding a rejuvenated energy to themselves with a coaching change, here are three reasons for optimism for the ...

The San Francisco 49ers’ exceedingly deep backfield thinned out rapidly when running backs Christian McCaffrey and Jordan ...

San Fransisco 49ers running back Christian McCaffrey already missed the first eight games of the NFL season due to ...