So far, the Celtics haven’t found a way to look like a contender without their star. Jaylen Brown (26.0 ppg) has picked up much of the scoring slack, but the loss of Tatum and Kristaps Porzingis has left this roster looking dangerously thin compared to last season.

Jaylen Brown led the hosts with 30 points, with 18 coming in the second quarter. Josh Minott (11 points, 14 rebounds), Payton Pritchard (10 points, 10 assists) and Neemias Queta (10 points, 13 rebounds) all chipped in with double-doubles in what was Minott’s second career start.

Tipoff is at 7 p.m. ET from TD Garden in Boston. Cleveland is a 3.5-point favorite in the latest Cavaliers vs. Celtics odds, while the over/under for total points scored is 234.5. Before locking in any Celtics vs. Cavaliers picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The Cleveland Cavaliers face the Boston Celtics in a regular season NBA game on Wednesday, Oct. 29, 2025 (10/29/25) at TD Garden in Boston, Mass.

Both the Boston Celtics and Cleveland Cavaliers may be without multiple key players in Wednesday night's matchup.

The Cleveland Cavaliers and the Boston Celtics meet Wednesday night at TD Garden in Boston, Massachusetts. Tip-off is scheduled for 7 p.m. ET.

Jaylen Brown scores 30 points as the Boston Celtics beat the Cleveland Cavaliers 125-105. Brown's 13 points during a 20-3 run helped Boston pull away.

Even though New Orleans is one of three teams that have yet to post a win, Monday’s 122-90 victory was an encouraging sign for a Celtics team that is still searching for an identity and was playing the second of back-to-back games.

This article was originally published on www.si.com/nba/cavaliers/onsi as Why the Cleveland Cavaliers were blown out by the Boston Celtics.

The 76ers and Celtics reveal the game statuses for Paul George and Jaylen Brown before their game on Friday night.

The Celtics have bounced back from a three-game losing streak with two straight wins after Wednesday's victory over the Cavs.