The Buffalo Bills are now slightly favored over the Kansas City Chiefs to finish as the No. 1 seed in the AFC.

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ...

San Francisco 49ers tight end George Kittle told reporters he had "no idea" why he received just two targets during a 35-10 ...

"GMFB" on what do you make of the Buffalo Bills Week 13 "Sunday Night Football" win vs. the San Francisco 49ers.

San Francisco 49ers quarterback Brock Purdy feels sorry for the brutal injury suffered by Christian McCaffrey.

In eight season’s San Francisco 49ers tight end George Kittle never played in Buffalo at Highmark Stadium. Despite the loss ...

Mike Florio and Chris Simms recap the 49ers loss to the Bills on SNF, including Christian McCaffrey's injury in the first ...

Mike Florio and Chris Simms unpack the Bills dominant victory over the 49ers in the snow in Week 13, and why Buffalo is "no ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Lake effect snow is slamming the Great Lakes, with seven states from Wisconsin to New York under snow alerts on Monday. In ...

The 49ers' disappointing season took another negative turn in their Week 13 loss to the Bills, and George Kittle addressed ...