The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Here are the full game day inactive lists for both the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup ...

We could be looking at a Winter Wonderland in Buffalo when the Bills host the 49ers in a December affair with playoff ...

Meanwhile, the 5-6 49ers are dealing with massive injury struggles. All-Pro left tackle Trent Williams, Defensive Player of ...

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Podcast; ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

San Francisco 49ers TE George Kittle, LB Fred Warner and QB Brock Purdy outlined the team's performance on "SNF" against the Buffalo Bills.

Three things I’m pondering as the Bills return from their bye for the stretch run… Mila-No More Waiting Matt Milano is ...

Here are the full injury reports for the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup at Highmark Stadium: ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

San Francisco will be without two of their biggest stars again, but should have their talented passer back in the saddle.

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.