The Bills return from their bye week with a tough test on Sunday Night Football. Here's a look ahead to the matchup.

Buffalo Bills quarterback Josh Allen is leading his team in a way he hasn't done in years prior, and it's a worry for the ...

If the award is truly about value, which is what the 'V' stands for, then Barkley should be at the front of the line.

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

Bill Bender breaks down his Week 13 NFL picks, including the Eagles continuing to roll and the Steelers getting back on track ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

The 49ers have a 17% chance of making the playoffs and have one of the toughest remaining schedules -- all while injuries ...

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...

San Francisco 49ers head coach Kyle Shanahan told reporters that quarterback Brock Purdy did some light throwing without any ...

Getting blown out in Green Bay following another squandered late lead the previous week against Seattle has quickly turned ...

San Francisco 49ers wide receiver Deebo Samuel has been a shadow of his usual dynamic self this season. With just 511 ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...