One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

Deebo Samuel speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium.Deebo ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

San Francisco 49ers wide receiver Deebo Samuel Sr. didn't do much to regain fantasy managers' confidence during a 35-10 defeat to the Bills in Buffalo on Sunday night. Samuel Sr. finished with four ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

ORCHARD PARK, NEW YORK – DECEMBER 01: Mack Hollins #13 of the Buffalo Bills celebrates after scoring a touchdown in the ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

San Francisco 49ers wide receiver Deebo Samuel returns the half-opening kick 60 yards into Buffalo Bills territory.

McCaffrey slid down untouched in the backfield after taking a toss, then immediately went to the 49ers' medical tent and ...

Follow along for updates throughout the game as the Buffalo Bills take on the San Francisco 49ers at snowy Highmark Stadium.

Brandon Allen is 2-8 in 10 career starts. One of them was against Josh Allen and the Bills but Brandon Allen wore No. 2 in ...