San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards.

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

49ers game in Buffalo on Sunday night. Snow fell steadily on Saturday and blanketed ... The weather could keep the Bills from ...

After the game, Bills quarterback Josh Allen and coach Sean McDermott soaked in the winter weather while celebrating the team ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

ORCHARD PARK, N.Y. (AP) — After U.S. travelers battled through harsh weekend weather to reach home following the Thanksgiving ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

Josh Allen makes NFL history as the Buffalo Bills clinch the AFC East, while the Philadelphia Eagles earn a statement win at ...

The Bills sacked Purdy twice, Greg Rousseau getting one while the other was called a team sack because Purdy lost a fumble ...