The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...