EMBO Press

From denaturant to ribosome: rethinking chaperone requirements in cells

DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...
EMBO Press

Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment

Activation of the complement cascade of proteases has been linked to autoimmune and kidney diseases, including systemic lupus ...
EMBO Press

Metabolic signatures for gastric cancer diagnosis and mechanistic insights: a multicenter study

A six-metabolite plasma panel was developed and validated for gastric cancer (GC) diagnosis using UPLC-MS and machine ...
The EMBO Journal

Deep learning for protein structure prediction and design—progress and applications

Proteins are the key molecular machines that orchestrate all biological processes of the cell. Most proteins fold into three-dimensional shapes that are critical for their function. Studying the 3D ...
The EMBO Journal

Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling

ER–mitochondria contact sites (ERMCSs) regulate processes, including calcium homoeostasis, energy metabolism and autophagy. Previously, it was shown that during growth factor signalling, mTORC2/Akt ...
The EMBO Journal

Thiol reductive stress activates the hypoxia response pathway

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Thiol antioxidant dithiothreitol (DTT) is used ...
The EMBO Journal

Deep learning for computational biology

Technological advances in genomics and imaging have led to an explosion of molecular and cellular profiling data from large numbers of samples. This rapid increase in biological data dimension and ...
The EMBO Journal

Exposomics: a review of methodologies, applications, and future directions in molecular medicine

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The exposome is the measure of all the ...
The EMBO Journal

SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The nucleoskeleton is essential for nuclear ...
The EMBO Journal

CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein quality control serves as the primary ...
The EMBO Journal

CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The connective tissue growth factor CTGF/CCN2 ...
The EMBO Journal

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Extracellular matrix (ECM) is a major ...