Bulk RNA sequencing provides cost-effective, population-level transcriptome insights, but averaging gene expression across all cells can mask important biological variability and obscure cellular ...

Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...

Researchers developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare diseases. The study team demonstrated that this ...

Diagnostic performance of SHOX2 and RASSF1A gene methylation assays in malignant pleural effusion: A systematic review and meta-analysis. This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come ...

For years, two siblings with the distinctive facial features of Treacher Collins syndrome had no genetic explanation for ...

Wayne Doyle earned his PhD at UT Southwestern and completed his postdoctoral training at UC San Diego. He previously worked at Active Motif, where he led the bioinformatics team, supporting biopharma ...

Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors ...

From Illumina to Nanopore to PacBio, getting high-quality sequencing data starts long before the run begins. Careful library prep, accurate quantification, platform-specific QC checks, and novel RNA ...

Single-cell sequencing is useful for a number of applications. For example, it can reveal cellular heterogeneity inside complex tissues, such as tumors. It can also provide information about how ...