News Medical

What are Cytochrome P450 Enzymes?

The superfamily of proteins called cytochrome P450 (CYP) enzymes are involved in the synthesis and metabolism of a range of internal and external cellular components. These enzymes have been ...
Nature

High-throughput fluorescence assay of cytochrome P450 3A4

Cytochrome P450 mono-oxygenases (P450s) are the principal enzymes involved in the oxidative metabolism of drugs and other xenobiotics. In this protocol, we describe a fluorescence-based, ...
Frontiers

Energy, Enzymes, and the Brain: From Cellular Pathways to Therapeutic Pharmacology in Neurological And Neurodegenerative Disorders

Neurodegenerative disorders are pressing global health challenges that stem from progressive neuronal dysfunction and loss. While the central roles of ...
Hosted on MSN

Study provides scaffold to selectively target drug breakdown process

Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration (FDA)-approved drugs, reducing their effectiveness. However, how to prevent CYPs from ...
ascopubs.org

Pharmacogenetics of Tamoxifen Biotransformation Is Associated With Clinical Outcomes of Efficacy and Hot Flashes

Outcome After Pathologic Complete Eradication of Cytologically Proven Breast Cancer Axillary Node Metastases Following Primary Chemotherapy We determined cytochrome P450 (CYP)2D6 (*4 and *6) and ...
ascopubs.org

Effects of strong cytochrome P450 (CYP)3A4 inducers/inhibitors on the pharmacokinetic (PK) profile of anamorelin in healthy volunteers.

Gut microbiome alterations in breast cancer survivors with cancer-related fatigue. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a full text ...