The oxidative folding of the Amaranthus α-amylase inhibitor, a 32-residue cystine-knot protein with three disulfide bridges, was studied in vitro in terms of the disulfide content of the intermediate ...

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way Cysteine is one of the many ...

Make room, disulfide crosslinks. There’s a new kind of crosslink in proteins. Instead of an S–S bridge connecting two cysteine residues, it consists of an N–O–S bridge between a lysine and a cysteine.

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

This research proposal presents a comprehensive investigation into the structural and functional integrity of disulfide bonds within therapeutic proteins, emphasizing their critical role in ...

Severe acute respiratory syndrome virus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), uses its spike (S) glycoprotein to enter host cells. The S glycoprotein consists of ...

Historically, much of weight loss advice focused on eating less and moving more. In recent times, researchers discovered that what, and not just how much, someone eats also influences weight loss and ...

A new wave of antibody-targeted anticancer therapies is showing great clinical promise, with the potential to transform cancer treatment. These antibody-drug conjugates (ADCs) are multicomponent ...

Scientists have uncovered a startling metabolic twist: mice engineered to lack the amino acid cysteine, and fed a cysteine-free diet, shed nearly a third of their body weight in just a week. The ...