The Supreme Court will dive headfirst into the politically fraught issue of transgender rights on Wednesday when it hears a challenge to Tennessee’s ban on gender-affirming care for minors in the highest-profile case of the fall.

The Supreme Court will consider if states can keep transgender adolescents from puberty blockers and hormone therapy, a major culture war flashpoint.

The Supreme Court is hearing arguments Wednesday in just its second major transgender rights case, a challenge to a Tennessee law that bans gender-affirming care for minors.