Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

Before looking at SportsbookWire staff's Week 13 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. The Detroit Lions (10-1 straight up) head into their Thanksgiving home game vs.

The Los Angeles Rams will hit the road to take on the New Orleans Saints in NFL Week 13 action. The Rams are still in the mix to win the NFC West, but a winnabl

Aaron Rodgers and the New York Jets have lost seven of their last eight games and now will host the Seattle Seahawks for a cross-conference matchup in Week 13. The Seahawks have won five straight against the Jets and Seattle is a two-point favorite according to the latest Week 13 NFL odds.

One fascinating matchup to watch for is wideout Courtland Sutton against cornerback Denzel Ward. The latter leads football with 17 passes deflected. And Sutton is enjoying his best season since his 2019 Pro Bowl campaign. He’s capable of acrobatic, catch-of-the-year grabs on any drive.

The Tennessee Titans pulled off a massive upset in Week 12, knocking off CJ Stroud and the Houston Texans to earn their third win of the season. Tennessee is no

NFL Week 13 picks, predictions, win probabilities for Chargers vs Falcons, Steelers vs Bengals, Eagles vs Ravens, 49ers vs Bills, this week's games.

Chris "The Bear" Fallica delivers his best bets for NFL Week 13. Check out his latest picks, including why he's fading the Rams offense against the Eagles.

Week 13 of the NFL season features Thanksgiving games and plenty of close matchups. Here are three teams who could beat the spread on Sunday.

SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games