San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle ...

RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Facing their seventh loss of the season, 49ers HC Kyle Shanahan gave an update on RB Christian McCaffrey who left the game ...

San Francisco running back Christian McCaffrey was officially ruled out of the 49ers’ Sunday Night Football contest at the ...

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team ...

After three strong weeks of play from 49ers RB Christian McCaffrey, he left the game against the Bills after suffering a knee ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

The 49ers running back went down with a non-contact knee injury early in San Francisco's 35-10 loss to the Buffalo Bills on ...